Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Gcg  glucagon   (Synonyms: GLP-1, Glu, glucagon-like peptide I, PPG)
Results	Reference
1	J:338878 Abarinov V, Levine JA, Churchill AJ, Hopwood B, Deiter CS, Guney MA, Wells KL, Schrunk JM, Guo Y, Hammelman J, Gifford DK, Magnuson MA, Wichterle H, Sussel L, Major beta cell-specific functions of NKX2.2 are mediated via the NK2-specific domain. Genes Dev. 2023 Jun 1;37(11-12):490-504
1	J:316658 Abdellatif AM, Ogata K, Kudo T, Xiafukaiti G, Chang YH, Katoh MC, El-Morsy SE, Oishi H, Takahashi S, Role of large MAF transcription factors in the mouse endocrine pancreas. Exp Anim. 2015;64(3):305-12
1	J:248945 Abdellatif AM, Oishi H, Itagaki T, Jung Y, Shawki HH, Okita Y, Hasegawa Y, Suzuki H, El-Morsy SE, El-Sayed MA, Shoaib MB, Sugiyama F, Takahashi S, beta-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development. PLoS One. 2016;11(2):e0150010
1	J:184016 Afelik S, Qu X, Hasrouni E, Bukys MA, Deering T, Nieuwoudt S, Rogers W, Macdonald RJ, Jensen J, Notch-mediated patterning and cell fate allocation of pancreatic progenitor cells. Development. 2012 May;139(10):1744-53
1	J:129667 Akpinar P, Kuwajima S, Krutzfeldt J, Stoffel M, Tmem27: a cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation. Cell Metab. 2005 Dec;2(6):385-97
1	J:70719 Allen-Jennings AE, Hartman MG, Kociba GJ, Hai T, The roles of atf3 in glucose homeostasis. a transgenic mouse model with liver dysfunction and defects in endocrine pancreas. J Biol Chem. 2001 Aug 3;276(31):29507-14
1	J:305792 Ansarullah, Jain C, Far FF, Homberg S, Wissmiller K, von Hahn FG, Raducanu A, Schirge S, Sterr M, Bilekova S, Siehler J, Wiener J, Oppenlander L, Morshedi A, Bastidas-Ponce A, Collden G, Irmler M, Beckers J, Feuchtinger A, Grzybek M, Ahlbrecht C, Feederle R, Plettenburg O, Muller TD, Meier M, Tschop MH, Coskun U, Lickert H, Inceptor counteracts insulin signalling in beta-cells to control glycaemia. Nature. 2021 Feb;590(7845):326-331
1	J:187468 Arnes L, Leclerc K, Friel JM, Hipkens SB, Magnuson MA, Sussel L, Generation of Nkx2.2:lacZ mice using recombination-mediated cassette exchange technology. Genesis. 2012 Aug;50(8):612-24
1	J:240765 Arregi I, Climent M, Iliev D, Strasser J, Gouignard N, Johansson JK, Singh T, Mazur M, Semb H, Artner I, Minichiello L, Pera EM, Retinol Dehydrogenase-10 Regulates Pancreas Organogenesis and Endocrine Cell Differentiation via Paracrine Retinoic Acid Signaling. Endocrinology. 2016 Dec;157(12):4615-4631
1	J:169626 Artner I, Hang Y, Mazur M, Yamamoto T, Guo M, Lindner J, Magnuson MA, Stein R, MafA and MafB regulate genes critical to beta-cells in a unique temporal manner. Diabetes. 2010 Oct;59(10):2530-9
1	J:106430 Artner I, Le Lay J, Hang Y, Elghazi L, Schisler JC, Henderson E, Sosa-Pineda B, Stein R, MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells. Diabetes. 2006 Feb;55(2):297-304
1	J:111685 Asayesh A, Sharpe J, Watson RP, Hecksher-Sorensen J, Hastie ND, Hill RE, Ahlgren U, Spleen versus pancreas: strict control of organ interrelationship revealed by analyses of Bapx1-/- mice. Genes Dev. 2006 Aug 15;20(16):2208-13
1	J:205003 Auffret J, Freemark M, Carre N, Mathieu Y, Tourrel-Cuzin C, Lombes M, Movassat J, Binart N, Defective prolactin signaling impairs pancreatic beta-cell development during the perinatal period. Am J Physiol Endocrinol Metab. 2013 Nov 15;305(10):E1309-18
1	J:260459 Azizoglu DB, Braitsch C, Marciano DK, Cleaver O, Afadin and RhoA control pancreatic endocrine mass via lumen morphogenesis. Genes Dev. 2017 Dec 1;31(23-24):2376-2390
1	J:151620 Back SH, Scheuner D, Han J, Song B, Ribick M, Wang J, Gildersleeve RD, Pennathur S, Kaufman RJ, Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells. Cell Metab. 2009 Jul;10(1):13-26
1	J:327292 Bakhti M, Bastidas-Ponce A, Tritschler S, Czarnecki O, Tarquis-Medina M, Nedvedova E, Jaki J, Willmann SJ, Scheibner K, Cota P, Salinno C, Boldt K, Horn N, Ueffing M, Burtscher I, Theis FJ, Coskun U, Lickert H, Synaptotagmin-13 orchestrates pancreatic endocrine cell egression and islet morphogenesis. Nat Commun. 2022 Aug 4;13(1):4540
1	J:204532 Balderes DA, Magnuson MA, Sussel L, Nkx2.2:Cre knock-in mouse line: A novel tool for pancreas- and CNS-specific gene deletion. Genesis. 2013 Dec;51(12):844-51
1	J:336187 Barlow HR, Ahuja N, Bierschenk T, Htike Y, Fassetta L, Azizoglu DB, Flores J, Gao N, De la O S, Sneddon JB, Marciano DK, Cleaver O, Rab11 is essential to pancreas morphogenesis, lumen formation and endocrine mass. Dev Biol. 2023 Jul;499:59-74
1	J:278226 Bastidas-Ponce A, Tritschler S, Dony L, Scheibner K, Tarquis-Medina M, Salinno C, Schirge S, Burtscher I, Bottcher A, Theis FJ, Lickert H, Bakhti M, Comprehensive single cell mRNA profiling reveals a detailed roadmap for pancreatic endocrinogenesis. Development. 2019 Jun 17;146(12):dev173849
1	J:334607 Bsharat S, Monni E, Singh T, Johansson JK, Achanta K, Bertonnier-Brouty L, Schmidt-Christensen A, Holmberg D, Kokaia Z, Prasad RB, Artner I, MafB-dependent neurotransmitter signaling promotes beta cell migration in the developing pancreas. Development. 2023 Mar 15;150(6):dev201009
1	J:307544 Burtscher I, Tarquis-Medina M, Salinno C, Schirge S, Beckenbauer J, Bakhti M, Lickert H, Generation of a Novel Nkx6-1 Venus Fusion Reporter Mouse Line. Int J Mol Sci. 2021 Mar 26;22(7)
1	J:284608 Campbell SA, McDonald CL, Krentz NAJ, Lynn FC, Hoffman BG, TrxG Complex Catalytic and Non-catalytic Activity Play Distinct Roles in Pancreas Progenitor Specification and Differentiation. Cell Rep. 2019 Aug 13;28(7):1830-1844.e6
1	J:312492 Chhabra NF, Amend AL, Bastidas-Ponce A, Sabrautzki S, Tarquis-Medina M, Sachs S, Rubey M, Lorenz-Depiereux B, Feuchtinger A, Bakhti M, Lickert H, Przemeck GKH, Hrabe de Angelis M, A point mutation in the Pdia6 gene results in loss of pancreatic beta-cell identity causing overt diabetes. Mol Metab. 2021 Sep 4;54:101334
1	J:269131 Cortijo C, Gouzi M, Tissir F, Grapin-Botton A, Planar cell polarity controls pancreatic beta cell differentiation and glucose homeostasis. Cell Rep. 2012 Dec 27;2(6):1593-606
1	J:297054 Cozzitorto C, Mueller L, Ruzittu S, Mah N, Willnow D, Darrigrand JF, Wilson H, Khosravinia D, Mahmoud AA, Risolino M, Selleri L, Spagnoli FM, A Specialized Niche in the Pancreatic Microenvironment Promotes Endocrine Differentiation. Dev Cell. 2020 Oct 26;55(2):150-162.e6
1	J:145696 Crawford LA, Guney MA, Oh YA, Deyoung RA, Valenzuela DM, Murphy AJ, Yancopoulos GD, Lyons KM, Brigstock DR, Economides A, Gannon M, Connective Tissue Growth Factor (CTGF) Inactivation Leads to Defects in Islet Cell Lineage Allocation and {beta}-Cell Proliferation during Embryogenesis. Mol Endocrinol. 2009 Mar;23(3):324-36
1	J:160437 Dames P, Puff R, Weise M, Parhofer KG, Goke B, Gotz M, Graw J, Favor J, Lechner A, Relative roles of the different Pax6 domains for pancreatic alpha cell development. BMC Dev Biol. 2010;10:39
1	J:332289 Dobosz AM, Janikiewicz J, Krogulec E, Dziewulska A, Ajduk A, Szpila M, Nieznanska H, Szczepankiewicz AA, Wypych D, Dobrzyn A, Inhibition of stearoyl-CoA desaturase 1 in the mouse impairs pancreatic islet morphogenesis and promotes loss of beta-cell identity and alpha-cell expansion in the mature pancreas. Mol Metab. 2022 Dec 15;67:101659
1	J:119914 Doyle MJ, Loomis ZL, Sussel L, Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet. Development. 2007 Feb;134(3):515-23
1	J:154416 Du A, Hunter CS, Murray J, Noble D, Cai CL, Evans SM, Stein R, May CL, Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas. Diabetes. 2009 Sep;58(9):2059-69
1	J:312856 Dudek KD, Osipovich AB, Cartailler JP, Gu G, Magnuson MA, Insm1, Neurod1, and Pax6 promote murine pancreatic endocrine cell development through overlapping yet distinct RNA transcription and splicing programs. G3 (Bethesda). 2021 Aug 26;
1	J:106827 Duvillie B, Currie C, Chrones T, Bucchini D, Jami J, Joshi RL, Hill DJ, Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin. Endocrinology. 2002 Apr;143(4):1530-7
1	J:267596 Escot S, Willnow D, Naumann H, Di Francescantonio S, Spagnoli FM, Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors. Nat Commun. 2018 Nov 30;9(1):5082
1	J:130389 Gannon M, Ables ET, Crawford L, Lowe D, Offield MF, Magnuson MA, Wright CV, pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev Biol. 2008 Feb 15;314(2):406-17
1	J:62627 Gannon M, Ray MK, Van Zee K, Rausa F, Costa RH, Wright CV, Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function. Development. 2000 Jul;127(13):2883-95
1	J:302364 Gausseres B, Liu J, Foppen E, Tourrel-Cuzin C, Rodriguez Sanchez-Archidona A, Delangre E, Cruciani-Guglielmacci C, Pons S, Maskos U, Thorens B, Magnan C, Movassat J, Maouche K, The Constitutive Lack of alpha7 Nicotinic Receptor Leads to Metabolic Disorders in Mouse. Biomolecules. 2020 Jul 16;10(7):1057
1	J:112173 Gierl MS, Karoulias N, Wende H, Strehle M, Birchmeier C, The Zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells. Genes Dev. 2006 Sep 1;20(17):2465-78
1*	J:152922 Golson ML, Le Lay J, Gao N, Bramswig N, Loomes KM, Oakey R, May CL, White P, Kaestner KH, Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas. Mech Dev. 2009 Aug-Sep;126(8-9):687-99
1*	J:125512 Goto Y, Nomura M, Tanaka K, Kondo A, Morinaga H, Okabe T, Yanase T, Nawata H, Takayanagi R, Li E, Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and the development of pancreas islets. Dev Dyn. 2007 Oct;236(10):2865-74
1	J:181586 Hald J, Galbo T, Rescan C, Radzikowski L, Sprinkel AE, Heimberg H, Ahnfelt-Ronne J, Jensen J, Scharfmann R, Gradwohl G, Kaestner KH, Stoeckert C Jr, Jensen JN, Madsen OD, Pancreatic islet and progenitor cell surface markers with cell sorting potential. Diabetologia. 2012 Jan;55(1):154-65
1*	J:84902 Hald J, Hjorth JP, German MS, Madsen OD, Serup P, Jensen J, Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. Dev Biol. 2003 Aug 15;260(2):426-37
1	J:214089 Hale MA, Swift GH, Hoang CQ, Deering TG, Masui T, Lee YK, Xue J, MacDonald RJ, The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis. Development. 2014 Aug;141(16):3123-33
1	J:57314 Harrison KA, Thaler J, Pfaff SL, Gu H, Kehrl JH, Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice. Nat Genet. 1999 Sep;23(1):71-5
1	J:65293 Hebrok M, Kim SK, St Jacques B, McMahon AP, Melton DA, Regulation of pancreas development by hedgehog signaling. Development. 2000 Nov;127(22):4905-13
1	J:108521 Heiser PW, Lau J, Taketo MM, Herrera PL, Hebrok M, Stabilization of {beta}-catenin impacts pancreas growth. Development. 2006 May;133(10):2023-32
1	J:238301 Henley KD, Stanescu DE, Kropp PA, Wright CV, Won KJ, Stoffers DA, Gannon M, Threshold-Dependent Cooperativity of Pdx1 and Oc1 in Pancreatic Progenitors Establishes Competency for Endocrine Differentiation and beta-Cell Function. Cell Rep. 2016 Jun 21;15(12):2637-50
1	J:98770 Henseleit KD, Nelson SB, Kuhlbrodt K, Hennings JC, Ericson J, Sander M, NKX6 transcription factor activity is required for {alpha}- and {beta}-cell development in the pancreas. Development. 2005 Jul;132(13):3139-49
1	J:254462 Hibsher D, Epshtein A, Oren N, Landsman L, Pancreatic Mesenchyme Regulates Islet Cellular Composition in a Patched/Hedgehog-Dependent Manner. Sci Rep. 2016 Nov 28;6:38008
1	J:142415 Hoffman BG, Zavaglia B, Beach M, Helgason CD, Expression of Groucho/TLE proteins during pancreas development. BMC Dev Biol. 2008;8:81
1	J:184814 Horn S, Kobberup S, Jorgensen MC, Kalisz M, Klein T, Kageyama R, Gegg M, Lickert H, Lindner J, Magnuson MA, Kong YY, Serup P, Ahnfelt-Ronne J, Jensen JN, Mind bomb 1 is required for pancreatic beta-cell formation. Proc Natl Acad Sci U S A. 2012 May 8;109(19):7356-61
1	J:208600 Hunter CS, Dixit S, Cohen T, Ediger B, Wilcox C, Ferreira M, Westphal H, Stein R, May CL, Islet alpha-, beta-, and delta-cell development is controlled by the Ldb1 coregulator, acting primarily with the islet-1 transcription factor. Diabetes. 2013 Mar;62(3):875-86
1	J:163480 Johansson JK, Voss U, Kesavan G, Kostetskii I, Wierup N, Radice GL, Semb H, N-cadherin is dispensable for pancreas development but required for beta-cell granule turnover. Genesis. 2010 Jun;48(6):374-81
1*	J:136705 Jonckheere N, Mayes E, Shih HP, Li B, Lioubinski O, Dai X, Sander M, Analysis of mPygo2 mutant mice suggests a requirement for mesenchymal Wnt signaling in pancreatic growth and differentiation. Dev Biol. 2008 Jun 15;318(2):224-35
1	J:141885 Juhl K, Sarkar SA, Wong R, Jensen J, Hutton JC, Mouse pancreatic endocrine cell transcriptome defined in the embryonic Ngn3-null mouse. Diabetes. 2008 Oct;57(10):2755-61
1	J:166952 Kalousova A, Mavropoulos A, Adams BA, Nekrep N, Li Z, Krauss S, Stainier DY, German MS, Dachshund homologues play a conserved role in islet cell development. Dev Biol. 2010 Dec 15;348(2):143-52
1	J:295408 Kanai M, Jeon H, Ojima M, Nishino T, Usui T, Yadav MK, Kulathunga K, Morito N, Takahashi S, Hamada M, Phenotypic analysis of mice carrying human-type MAFB p.Leu239Pro mutation. Biochem Biophys Res Commun. 2020 Mar 5;523(2):452-457
1*	J:85472 Kawahira H, Ma NH, Tzanakakis ES, McMahon AP, Chuang PT, Hebrok M, Combined activities of hedgehog signaling inhibitors regulate pancreas development. Development. 2003 Oct;130(20):4871-9
1	J:236027 Khoriaty R, Everett L, Chase J, Zhu G, Hoenerhoff M, McKnight B, Vasievich MP, Zhang B, Tomberg K, Williams J, Maillard I, Ginsburg D, Pancreatic SEC23B deficiency is sufficient to explain the perinatal lethality of germline SEC23B deficiency in mice. Sci Rep. 2016 Jun 14;6:27802
1*	J:79280 Kido Y, Nakae J, Hribal ML, Xuan S, Efstratiadis A, Accili D, Effects of Mutations in the Insulin-like Growth Factor Signaling System on Embryonic Pancreas Development and beta -Cell Compensation to Insulin Resistance. J Biol Chem. 2002 Sep 27;277(39):36740-7
1	J:306154 Kim A, Miller K, Jo J, Kilimnik G, Wojcik P, Hara M, Islet architecture: A comparative study. Islets. 2009 Sep-Oct;1(2):129-36
1	J:257425 Kim DS, Song L, Wang J, Wu H, Gu G, Sugi Y, Li Z, Wang H, GRP94 Is an Essential Regulator of Pancreatic beta-Cell Development, Mass, and Function in Male Mice. Endocrinology. 2018 Feb 1;159(2):1062-1073
1	J:112755 Kim HJ, Schleiffarth JR, Jessurun J, Sumanas S, Petryk A, Lin S, Ekker SC, Wnt5 signaling in vertebrate pancreas development. BMC Biol. 2005;3:23
1	J:306907 Kodani N, Nakae J, Kobayashi M, Kikuchi O, Kitamura T, Itoh H, FCoR-Foxo1 Axis Regulates alpha-Cell Mass through Repression of Arx Expression. iScience. 2020 Jan 24;23(1):100798
1	J:138261 Kokubu H, Ohtsuka T, Kageyama R, Mash1 is required for neuroendocrine cell development in the glandular stomach. Genes Cells. 2008 Jan;13(1):41-51
1	J:170126 Kopp JL, Dubois CL, Schaffer AE, Hao E, Shih HP, Seymour PA, Ma J, Sander M, Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development. 2011 Feb;138(4):653-65
1*	J:182781 Landsman L, Nijagal A, Whitchurch TJ, Vanderlaan RL, Zimmer WE, Mackenzie TC, Hebrok M, Pancreatic mesenchyme regulates epithelial organogenesis throughout development. PLoS Biol. 2011 Sep;9(9):e1001143
1	J:239872 Larsen BM, Hrycaj SM, Newman M, Li Y, Wellik DM, Mesenchymal Hox6 function is required for mouse pancreatic endocrine cell differentiation. Development. 2015 Nov 15;142(22):3859-68
1	J:220325 Lemaire LA, Goulley J, Kim YH, Carat S, Jacquemin P, Rougemont J, Constam DB, Grapin-Botton A, Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis. Development. 2015 Mar 1;142(5):858-70
1	J:189468 Lenoir O, Flosseau K, Ma FX, Blondeau B, Mai A, Bassel-Duby R, Ravassard P, Olson EN, Haumaitre C, Scharfmann R, Specific control of pancreatic endocrine beta- and delta-cell mass by class IIa histone deacetylases HDAC4, HDAC5, and HDAC9. Diabetes. 2011 Nov;60(11):2861-71
1	J:211812 Lindahl M, Danilova T, Palm E, Lindholm P, Voikar V, Hakonen E, Ustinov J, Andressoo JO, Harvey BK, Otonkoski T, Rossi J, Saarma M, MANF is indispensable for the proliferation and survival of pancreatic beta cells. Cell Rep. 2014 Apr 24;7(2):366-75
1*	J:84446 Lioubinski O, Muller M, Wegner M, Sander M, Expression of Sox transcription factors in the developing mouse pancreas. Dev Dyn. 2003 Jul;227(3):402-8
1	J:236958 Lu J, Herrera PL, Carreira C, Bonnavion R, Seigne C, Calender A, Bertolino P, Zhang CX, Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development. Gastroenterology. 2010 May;138(5):1954-65
1*	J:132315 Lynn FC, Skewes-Cox P, Kosaka Y, McManus MT, Harfe BD, German MS, MicroRNA expression is required for pancreatic islet cell genesis in the mouse. Diabetes. 2007 Dec;56(12):2938-45
1	J:225823 Martin D, Kim YH, Sever D, Mao CA, Haefliger JA, Grapin-Botton A, REST represses a subset of the pancreatic endocrine differentiation program. Dev Biol. 2015 Sep 15;405(2):316-27
1	J:334331 Melzer MK, Schirge S, Gout J, Arnold F, Srinivasan D, Burtscher I, Allgower C, Mulaw M, Zengerling F, Gunes C, Lickert H, Christoffels VM, Liebau S, Wagner M, Seufferlein T, Bolenz C, Moon AM, Perkhofer L, Kleger A, TBX3 is dynamically expressed in pancreatic organogenesis and fine-tunes regeneration. BMC Biol. 2023 Mar 20;21(1):55
1	J:321671 Monica Shih MC, Huang CC, Chu HP, Hsu NC, Chung BC, Embryonic Steroids Control Developmental Programming of Energy Balance. Endocrinology. 2021 Dec 1;162(12)
1	J:254493 Munoz-Bravo JL, Flores-Martinez A, Herrero-Martin G, Puri S, Taketo MM, Rojas A, Hebrok M, Cano DA, Loss of Pancreas upon Activated Wnt Signaling Is Concomitant with Emergence of Gastrointestinal Identity. PLoS One. 2016;11(10):e0164714
1	J:321229 Murakami-Kawaguchi S, Takasawa S, Onogawa T, Nata K, Itaya-Hironaka A, Sakuramoto-Tsuchida S, Yamauchi A, Ota H, Takeda M, Kato M, Okamoto H, Expression of Ins1 and Ins2 genes in mouse fetal liver. Cell Tissue Res. 2014 Feb;355(2):303-14
1	J:139250 Nakhai H, Siveke JT, Klein B, Mendoza-Torres L, Mazur PK, Algul H, Radtke F, Strobl L, Zimber-Strobl U, Schmid RM, Conditional ablation of Notch signaling in pancreatic development. Development. 2008 Aug;135(16):2757-65
1	J:138933 Nakhai H, Siveke JT, Mendoza-Torres L, Schmid RM, Conditional inactivation of Myc impairs development of the exocrine pancreas. Development. 2008 Oct;135(19):3191-6
1	J:122518 Nelson SB, Schaffer AE, Sander M, The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells. Development. 2007 Jul;134(13):2491-500
1*	J:86842 Norgaard GA, Jensen JN, Jensen J, FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development. Dev Biol. 2003 Dec 15;264(2):323-38
1	J:284168 Nyeng P, Heilmann S, Lof-Ohlin ZM, Pettersson NF, Hermann FM, Reynolds AB, Semb H, p120ctn-Mediated Organ Patterning Precedes and Determines Pancreatic Progenitor Fate. Dev Cell. 2019 Apr 8;49(1):31-47.e9
1	J:134393 Nyeng P, Norgaard GA, Kobberup S, Jensen J, FGF10 signaling controls stomach morphogenesis. Dev Biol. 2007 Mar 1;303(1):295-310
1*	J:32017 Offield MF, Jetton TL, Labosky PA, Ray M, Stein RW, Magnuson MA, Hogan BL, Wright CV, PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development. 1996 Mar;122(3):983-95
1	J:191410 Ohta Y, Kosaka Y, Kishimoto N, Wang J, Smith SB, Honig G, Kim H, Gasa RM, Neubauer N, Liou A, Tecott LH, Deneris ES, German MS, Convergence of the insulin and serotonin programs in the pancreatic beta-cell. Diabetes. 2011 Dec;60(12):3208-16
1*	J:235223 Omori H, Ogaki S, Sakano D, Sato M, Umeda K, Takeda N, Nakagata N, Kume S, Changes in expression of C2cd4c in pancreatic endocrine cells during pancreatic development. FEBS Lett. 2016 Aug;590(16):2584-93
1	J:306470 Osipovich AB, Dudek KD, Greenfest-Allen E, Cartailler JP, Manduchi E, Potter Case L, Choi E, Chapman AG, Clayton HW, Gu G, Stoeckert CJ Jr, Magnuson MA, A developmental lineage-based gene co-expression network for mouse pancreatic beta-cells reveals a role for Zfp800 in pancreas development. Development. 2021 Mar 21;148(6):dev196964
1	J:214095 Osipovich AB, Long Q, Manduchi E, Gangula R, Hipkens SB, Schneider J, Okubo T, Stoeckert CJ Jr, Takada S, Magnuson MA, Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3. Development. 2014 Aug;141(15):2939-49
1	J:336513 Patzek S, Liu Z, de la O S, Chang S, Byrnes LE, Zhang X, Ornitz DM, Sneddon JB, Loss of Fgf9 in mice leads to pancreatic hypoplasia and asplenia. iScience. 2023 Apr 21;26(4):106500
1	J:209016 Piccand J, Meunier A, Merle C, Jia Z, Barnier JV, Gradwohl G, Pak3 promotes cell cycle exit and differentiation of beta-cells in the embryonic pancreas and is necessary to maintain glucose homeostasis in adult mice. Diabetes. 2014 Jan;63(1):203-15
1*	J:169398 Prasadan K, Koizumi M, Tulachan S, Shiota C, Lath N, Paredes J, Guo P, El-Gohary Y, Malek M, Shah S, Gittes GK, The expression and function of glucose-dependent insulinotropic polypeptide in the embryonic mouse pancreas. Diabetes. 2011 Feb;60(2):548-54
1	J:251520 Pujadas G, Cervantes S, Tutusaus A, Ejarque M, Sanchez L, Garcia A, Esteban Y, Fargas L, Alsina B, Hartmann C, Gomis R, Gasa R, Wnt9a deficiency discloses a repressive role of Tcf7l2 on endocrine differentiation in the embryonic pancreas. Sci Rep. 2016 Jan 14;6:19223
1*	J:82083 Pulkkinen MA, Spencer-Dene B, Dickson C, Otonkoski T, The IIIb isoform of fibroblast growth factor receptor 2 is required for proper growth and branching of pancreatic ductal epithelium but not for differentiation of exocrine or endocrine cells. Mech Dev. 2003 Feb;120(2):167-75
1*	J:246476 Raum JC, Soleimanpour SA, Groff DN, Core N, Fasano L, Garratt AN, Dai C, Powers AC, Stoffers DA, Tshz1 Regulates Pancreatic beta-Cell Maturation. Diabetes. 2015 Aug;64(8):2905-14
1	J:41624 Sander M, Neubuser A, Kalamaras J, Ee HC, Martin GR, German MS, Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. Genes Dev. 1997 Jul 1;11(13):1662-73
1	J:195153 Schaffer AE, Taylor BL, Benthuysen JR, Liu J, Thorel F, Yuan W, Jiao Y, Kaestner KH, Herrera PL, Magnuson MA, May CL, Sander M, Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity. PLoS Genet. 2013 Jan;9(1):e1003274
1*	J:63215 Schwitzgebel VM, Scheel DW, Conners JR, Kalamaras J, Lee JE, Anderson DJ, Sussel L, Johnson JD, German MS, Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. Development. 2000 Aug;127(16):3533-42
1	J:297252 Seymour PA, Collin CA, Egeskov-Madsen AR, Jorgensen MC, Shimojo H, Imayoshi I, de Lichtenberg KH, Kopan R, Kageyama R, Serup P, Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors. Dev Cell. 2020 Mar 23;52(6):731-747.e8
1	J:141017 Seymour PA, Freude KK, Dubois CL, Shih HP, Patel NA, Sander M, A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation. Dev Biol. 2008 Nov 1;323(1):19-30
1	J:119758 Seymour PA, Freude KK, Tran MN, Mayes EE, Jensen J, Kist R, Scherer G, Sander M, SOX9 is required for maintenance of the pancreatic progenitor cell pool. Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1865-70
1	J:242899 Sinagoga KL, Stone WJ, Schiesser JV, Schweitzer JI, Sampson L, Zheng Y, Wells JM, Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets. Development. 2017 Jul 01;144(13):2402-2414
1	J:156925 Smith SB, Qu HQ, Taleb N, Kishimoto NY, Scheel DW, Lu Y, Patch AM, Grabs R, Wang J, Lynn FC, Miyatsuka T, Mitchell J, Seerke R, Desir J, Eijnden SV, Abramowicz M, Kacet N, Weill J, Renard ME, Gentile M, Hansen I, Dewar K, Hattersley AT, Wang R, Wilson ME, Johnson JD, Polychronakos C, German MS, Rfx6 directs islet formation and insulin production in mice and humans. Nature. 2010 Feb 11;463(7282):775-80
1	J:225920 Spaeth JM, Hunter CS, Bonatakis L, Guo M, French CA, Slack I, Hara M, Fisher SE, Ferrer J, Morrisey EE, Stanger BZ, Stein R, The FOXP1, FOXP2 and FOXP4 transcription factors are required for islet alpha cell proliferation and function in mice. Diabetologia. 2015 Aug;58(8):1836-44
1	J:198781 Sugiyama T, Benitez CM, Ghodasara A, Liu L, McLean GW, Lee J, Blauwkamp TA, Nusse R, Wright CV, Gu G, Kim SK, Reconstituting pancreas development from purified progenitor cells reveals genes essential for islet differentiation. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12691-6
1	J:48576 Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA , Rubenstein JL , German MS, Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development. 1998 Jun;125(12):2213-21
1	J:186391 Tao J, Zhu M, Wang H, Afelik S, Vasievich MP, Chen XW, Zhu G, Jensen J, Ginsburg D, Zhang B, SEC23B is required for the maintenance of murine professional secretory tissues. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):E2001-9
1	J:316197 Tennant BR, Chen J, Shih AZ, Luciani DS, Hoffman BG, Myt3 Mediates Laminin-V/Integrin-beta1-Induced Islet-Cell Migration via Tgfbi. Mol Endocrinol. 2015 Sep;29(9):1254-68
1	J:307817 Theis A, Singer RA, Garofalo D, Paul A, Narayana A, Sussel L, Groucho co-repressor proteins regulate beta cell development and proliferation by repressing Foxa1 in the developing mouse pancreas. Development. 2021 Mar 24;148(6):dev192401
1	J:339475 Toren E, Kepple JD, Coutinho KV, Poole SO, Deeba IM, Pierre TH, Liu Y, Bethea MM, Hunter CS, The SSBP3 co-regulator is required for glucose homeostasis, pancreatic islet architecture, and beta-cell identity. Mol Metab. 2023 Aug 1;76:101785
1	J:121629 Tulachan SS, Tei E, Hembree M, Crisera C, Prasadan K, Koizumi M, Shah S, Guo P, Bottinger E, Gittes GK, TGF-beta isoform signaling regulates secondary transition and mesenchymal-induced endocrine development in the embryonic mouse pancreas. Dev Biol. 2007 May 15;305(2):508-521
1	J:121610 Vanhorenbeeck V, Jenny M, Cornut JF, Gradwohl G, Lemaigre FP, Rousseau GG, Jacquemin P, Role of the Onecut transcription factors in pancreas morphogenesis and in pancreatic and enteric endocrine differentiation. Dev Biol. 2007 May 15;305(2):685-94
1	J:292264 Vinckier NK, Patel NA, Geusz RJ, Wang A, Wang J, Matta I, Harrington AR, Wortham M, Wetton N, Wang J, Jhala US, Rosenfeld MG, Benner CW, Shih HP, Sander M, LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development. Nat Commun. 2020 Apr 29;11(1):2082
1	J:87406 Wang J, Elghazi L, Parker SE, Kizilocak H, Asano M, Sussel L, Sosa-Pineda B, The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation. Dev Biol. 2004 Feb 1;266(1):178-89
1	J:150074 Wang S, Jensen JN, Seymour PA, Hsu W, Dor Y, Sander M, Magnuson MA, Serup P, Gu G, Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9715-20
1*	J:127471 Wang S, Zhang J, Zhao A, Hipkens S, Magnuson MA, Gu G, Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse. Mech Dev. 2007 Nov-Dec;124(11-12):898-910
1	J:208919 Wei J, Hanna T, Suda N, Karsenty G, Ducy P, Osteocalcin promotes beta-cell proliferation during development and adulthood through Gprc6a. Diabetes. 2014 Mar;63(3):1021-31
1	J:209317 Wilcox CL, Terry NA, May CL, Arx polyalanine expansion in mice leads to reduced pancreatic alpha-cell specification and increased alpha-cell death. PLoS One. 2013;8(11):e78741
1	J:132695 Wilding Crawford L, Tweedie Ables E, Oh YA, Boone B, Levy S, Gannon M, Gene expression profiling of a mouse model of pancreatic islet dysmorphogenesis. PLoS One. 2008;3(2):e1611
1*	J:77320 Wilson ME, Kalamaras JA, German MS, Expression pattern of IAPP and prohormone convertase 1/3 reveals a distinctive set of endocrine cells in the embryonic pancreas. Mech Dev. 2002 Jul;115(1-2):171-6
1	J:289313 Xiafukaiti G, Maimaiti S, Ogata K, Kuno A, Kudo T, Shawki HH, Oishi H, Takahashi S, MafB Is Important for Pancreatic beta-Cell Maintenance under a MafA-Deficient Condition. Mol Cell Biol. 2019 Sep 1;39(17)
1	J:220744 Xu EE, Krentz NA, Tan S, Chow SZ, Tang M, Nian C, Lynn FC, SOX4 cooperates with neurogenin 3 to regulate endocrine pancreas formation in mouse models. Diabetologia. 2015 May;58(5):1013-23
1	J:73284 Yang Q, Bermingham NA, Finegold MJ, Zoghbi HY, Requirement of Math1 for secretory cell lineage commitment in the mouse intestine. Science. 2001 Dec 7;294(5549):2155-8
1	J:86239 Yoshida T, Tokunaga A, Nakao K, Okano H, Distinct expression patterns of splicing isoforms of mNumb in the endocrine lineage of developing pancreas. Differentiation. 2003 Oct;71(8):486-495
1	J:89465 Zaiko M, Estreicher A, Ritz-Laser B, Herrera P, Favor J, Meda P, Philippe J, Pax2 mutant mice display increased number and size of islets of Langerhans but no change in insulin and glucagon content. Eur J Endocrinol. 2004 Mar;150(3):389-95
1*	J:155058 Zhang H, Ables ET, Pope CF, Washington MK, Hipkens S, Means AL, Path G, Seufert J, Costa RH, Leiter AB, Magnuson MA, Gannon M, Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation. Mech Dev. 2009 Dec;126(11-12):958-73